منابع مشابه
Biosynthesis of Valine and Isoleucine
The isotope studies of Strassman et al. (3, 4) first implicated cu-acetolactate and cu-aceto-cY-hydroxybutyrate as biosynthetic precursors of valine and isoleucine, respectively. The observed accumulation of acetolactate by Escherichia coli (5, 6) and of the decarboxylation products of acetolactate and acetohydroxybutyrate by Neurospora crassa (7) when mutants of these organisms are grown with ...
متن کاملBiosynthesis of Valine and Isoleucine
Evidence published in recent years has shown that the biosynthesis of valine and isoleucine proceeds by a similar sequence of reactions (24). Fig. 1 depicts the reactions considered to be involved. In this report only Reactions II, III, and IV will be considered. Reaction II, the isomerization of the Lu-hydroxy$keto acid (ac-acetolactate for valine biosynthesis and a-aceto-a-hydroxybutyrate for...
متن کاملControl of isoleucine, valine, and leucine biosynthesis. I. Multivalent repression.
Repression of the formation of biosynthetic enzymes by the ultimate end product of their action has been shown to be an important aspect of metabolic regulation in microorganisms.1 In Escherichia coli and Salmonella typhimuwium each of the last four steps in the synthesis of valine and isoleucine is catalyzed by the same enzymes.2 Repression of these enzymes presents a unique situation since tw...
متن کاملInterference with valine and isoleucine biosynthesis by cyclic hydroxamic acids.
Hogg, Robert W. (University of Illinois, Urbana), Chitra S. Biswas, and Harry P. Broquist. Interference with valine and isoleucine biosynthesis by cyclic hydroxamic acids. J. Bacteriol. 90:1265-1270. 1965.-The introduction of a hydroxyl group in a number of common barbiturates, a substitution which converts these compounds to cyclic hydroxamic acids, gives rise to compounds which inhibit growth...
متن کاملMultivalent repression of isoleucine- valine biosynthesis in Saccharomyces cerevisiae.
Regulation of the biosynthesis of four of the five enzymes of the isoleucine-valine pathway was studied in Saccharomyces cerevisiae. A method is described for limiting the growth of a leucine auxotroph by using valine as a competitor for the permease. Limitation for isoleucine and valine was accomplished by the use of peptides containing these amino acids conjugated with glycine as nutritional ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1960
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)64621-6